Acid suppressive agents and risk of Mycobacterium Tuberculosis: case–control study
نویسندگان
چکیده
BACKGROUND The acid-suppressive agents have been linked with an increased risk of infectious disease. The relationship between these drugs and Mycobacterium Tuberculosis (TB) was not been reported. METHODS We conducted a case-control study using data from National Health Insurance research database of Taiwan. From 1996 till 2008, and 6541 cases were defined as TB infection/activation (ICD-9 coding plus prescription two of four first-line anti-TB regimen for at least one month). Control subjects who were matched to the TB cases by age and sex were selected with 10:1 ratio. Medical records including acid-suppressive agent prescription and comorbidity, and socioeconomic status were analyzed. RESULTS TB infection/activation was more frequent to comorbidity with chronic diseases, alcohol abuse, malignancy, immune deficient/suppression status and acid-related disease (peptic ulcer, reflux esophagitis). Among the TB cases, there was higher exposure record to acid-suppressive agents within 3 months before TB index date (OR 2.43(2.06-2.88) and 1.90 (1.68-2.14) for proton pump inhibitor (PPI) and histamine 2 receptor antagonist (H2RA) respectively). After adjusting confounding factors, PPIs prescription 3 months before TB index date had an association of TB infection/activation (adjusted OR 1.63(1.61-1.63)). Similar result was found in H2RA user (adjusted OR 1.51(1.50-1.52)). The association of acid-suppressive agents in TB infection/activation was fade gradually when the drug prescription period extended. CONCLUSIONS Recent prescription of acid-suppressive agent seems to associate the TB infection/activation. In the society where TB was prevalent, evaluation of pulmonary TB before prescription of PPI or H2RA is warranted.
منابع مشابه
عفونت سل نهفته در کارکنان مراکز درمانی: مقاله مروری
The members of Mycobacterium tuberculosis complex (MTBC) known as causative agents of human tuberculosis. Tuberculosis infection is one of the most important occupational risks for healthcare workers (HCWs) in most countries, such as Iran. In general, there are two types of tuberculosis, they include: latent infection and active TB. Latent tuberculosis infection (LTBI) means: a patient is infec...
متن کاملPoint-Mutations in embB306 Gene and Their Association with Resistance to Ethambutol in Mycobacterium tuberculosis in Clinical Isolates
Background & Objective: Mutations in embB306 gene and their association with resistance to ethambutol (EMB) in Mycobacterium tuberculosis (M. tuberculosis) have not been fully investigated. The aim of this study was to investigate the point-mutations in emb306B gene and their association with resistance to EMB in M. tuberculosis. Materials & Methods: This case (M. tuberculosis resistant to EMB...
متن کاملبررسی میزان وفور ژنوتیپ بیجینگ در سویههای مایکوباکتریوم توبرکلوزیس جدا شده از بیماران مسلولThe Frequency of Beijing Genotype of Mycobacterium Tuberculosis Isolated from Tuberculosis Patients
Background & Aim: Molecular epidemiology is the using of molecular techniques (e.g. Spoligotyping, RFLP VNTR) in order to study bacterial distribution in human populations. The aim of this study was to investigate the prevalence of all genotypes in M. tuberculosis strains typed by spoligotyping and to determine the associated risk factors in patients with different nationalities residing in...
متن کاملAnti-Mycobacterium Tuberculosis Effects of Folk Medicinal Plants in Iran: A Mini-Systematic Review
The emergence of drug resistance in Mycobacterium tuberculosis is a major challenge in tuberculosis treatment and control. In addition, multidrug resistance (MDR) and, more broadly, extensive drug resistance (XDR) have hampered treatment with common antibiotics. Thus, an herbal medicine containing antimicrobial capability can be a good alternative to antituberculosis drugs. In this study, we re...
متن کاملDetection of Non-Tuberculosis Mycobacteria Infection due to Mycobacterium leprae and Mycobacterium kansasii in Patients Suspected of Tuberculosis in Isfahan, Iran
Several reports have indicated that infection with Non-Tuberculosis Mycobacteria (NTM) is increasing worldwide.Therefore,monitoring species causing micobacterial infection in any region is of great importance. This study was going to detect, differentiate, and identify pathogenic mycobacteria in primary clinical samples. Eighty samples collected from tuberculosis suspected patients in Isfahan/I...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2014